Association·nasa
Local DMRs may be undetectable in global methylation analysis
WGBS data reveals local hypo- and hypermethylation, while global DNA methylation (UPLC-MS/MS) may not capture these changes because increases and decreases can cancel each other out.
Confidence
85%
active
Evidence Quote
“A strong response found in WGBS data in S2 is potentially not picked up in UPLC-MS/MS global DNA methylation percentage, as hypo- and hypermethylation changes will cancel each other out”
Relationship
global DNA methylation undetected hypermethylation