InferenceChain·nasa

Identifiability analysis of model parameters using MOTA tool

Analysis using the MOTA tool reduced the number of free parameters in the gene expression model from 17 non-identifiable to 10 identifiable parameters by fixing related parameters stepwise.

Confidence
80%
◑partialactivecomplexity: mid

Reasoning Steps (2)

Fixing specific parameters improves identifiabilityStep 1
Parameter sets analyzed for statistical dependenceStep 2

Source

Synthesis for current paper

Connections (4)

Constancy of pool sizes for Phy and PIF3 fusions in yeast systemAssociation
Mass Action kinetics describes complex formation/dissociationAssociation
Hill function used to model switch-like transcription activationAssociation
Reporter reaction modeled with Michaelis-Menten kineticsAssociation