Association·nasa

DEMETER and ROS1 encode 5-mC DNA glycosylases

DEMETER and ROS1 genes encode enzymes catalyzing removal of 5-methylcytosine from DNA in plants.

Confidence
90%
active

Evidence Quote

DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.

Relationship

DEMETER and ROS1 DNA glycosylases encodes 5-methylcytosine DNA glycosylase activity

Evidence

Reference to Morales-Ruiz et al. (2006), reporting that DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases in plants.

Morales-Ruiz, T. et al. (2006). DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases. doi:10.1073/pnas.0601109103

Reference to Tang et al. (2016), identifying that the DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications in Arabidopsis.

Tang, K. et al. (2016). The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications