Association·nasa
Batch effects impact DEG identification
Claim that batch effects and confounding variables affect identification of differentially expressed genes (DEGs) across spaceflight transcriptome experiments.
Confidence
100%
active
Evidence Quote
“Batch effects became evident and impact DEGs across studies”
Relationship
batch effects affects DEGs
Connections (2)
Evidence
“Method for batch-effect correction in RNA-seq data”
Fei, T. & Yu, T. (2020). ScBatch: Batch-effect correction of RNA-seq data through sample distance matrix adjustment link ↗
“Study on confounding factors in RNAseq analysis of rodent spaceflight experiments”
Lai Polo, S.-H. & et al. (2020). RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques link ↗
“Comparison of different software packages for detecting differential expression in RNA-seq data”
Seyednasrollah, F. et al. (2015). Comparison of software packages for detecting differential expression in RNA-seq studies link ↗