Fylo›ARCADIA›Graph
Hubs

Statistical separation and properties of structurally rigid and plastic protein families — ARCADIA Knowledge Graph

InferenceChain·arcadia

Statistical separation and properties of structurally rigid and plastic protein families

This reasoning chain explains why structurally rigid and structurally plastic Asgard protein families form statistically distinct categories by integrating TM-score, sequence divergence, and domain/disorder metrics.

Confidence
90%
◑partialactivecomplexity: mid

Reasoning Steps (3)

TM-score and APSI separate rigid and plastic familiesStep 1
Domain count but not intrinsic disorder distinguishes rigidityStep 2
Structural rigidity is not due to recent evolutionStep 3

Source

Synthesis for current paper

Connections (3)

Difference in Shannon entropy between structural profilesAssociation
Difference in APSI between structural profilesAssociation
Difference in domain complexity between structural profilesAssociation