InferenceChain·arcadia

Sign epistasis and evolutionary constraints impact BFM learning

Reasoning that sign epistasis and genetic constraints limit evolutionary trajectories, influencing biological foundation models’ ability to learn and predict evolutionary patterns and variant effects.

Confidence
85%
◑partialactivecomplexity: mid

Reasoning Steps (3)

Sign epistasis limits generalizationStep 1
Improving variant effect prediction informs model limitsStep 2
Gene origination times shape model training scopeStep 3

Source

Training on the Test Task Confounds Evaluation and Emergence