Association·arcadia
Phospholipase D gene may contribute to Cordyceps virulence
Claim that actinomycete-derived phospholipase D gene in Cordyceps sp. RAO-2017 may act as a virulence factor and contribute to disruption of host membranes and insect pathogenesis.
Confidence
70%
active
Evidence Quote
“Phospholipase D gene acts as virulence factor in Cordyceps”
Relationship
Phospholipase D gene in Cordyceps sp. RAO-2017 enables Cordyceps virulence and host membrane disruption
Arguments
Connections (5)
Reasoning about functional significance of HGT candidate genes in fungal behavioral manipulation and pathogenicityInferenceChain
Polyketide synthase gene derived from actinomycetes may mediate bioactive metabolite production in CordycepsAssociation
Horizontally transferred genes support host manipulation and pathogenicityInferenceChain
Bioinformatic tools enable HGT detection and annotationInferenceChain
CFEM, phospholipase, and fungal virulence reasoning chainInferenceChain
Evidence
“Reference discussing phospholipases in the context of fungal pathogenicity and potential roles in drug development.”
Djordjevic JT (2010). Role of Phospholipases in Fungal Fitness, Pathogenicity, and Drug Development – Lessons from Cryptococcus Neoformans doi:10.3389/fmicb.2010.00125 ↗
“Reference addressing the roles of host lipids in pathogen interactions and exploitation of the host lipidome.”
van der Meer-Janssen YPM et al. (2010). Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome doi:10.1016/j.plipres.2009.07.003 ↗
“Reference reporting new sphingomyelinase D enzymes identified in pathogenic fungi and other organisms.”
Dias-Lopes C et al. (2013). Identification of New Sphingomyelinases D in Pathogenic Fungi and Other Pathogenic Organisms doi:10.1371/journal.pone.0079240 ↗
“Study on the evolutionary history of phospholipase D toxin genes, focusing on their origins and losses across diverse taxa.”
(2018). Evolutionary dynamics of origin and loss in the deep history of phospholipase D toxin genes doi:10.1186/s12862-018-1302-2 ↗
“Comprehensive review discussing the enzymology, functions, and chemical modulation of phospholipase D enzymes.”
Selvy PE et al. (2011). Phospholipase D: Enzymology, Functionality, and Chemical Modulation doi:10.1021/cr200296t ↗