Pathway and molecular basis of arabinose modification in Serratia phage 92A1 | ARCADIA FyloGraph | FyloGraph

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Pathway and molecular basis of arabinose modification in Serratia phage 92A1

Reasoning chain linking nucleoside HPLC evidence, genome sequencing, and comparative genomics to support the claim that Serratia phage 92A1 uses arabinose to hypermodify hydroxymethylcytosine in its DNA, although the exact glycosyltransferase and the potential novel role of U32 peptidase remain unresolved.

Confidence

90%

◑partialactivecomplexity: mid

Reasoning Steps (3)

HPLC profile indicates 100% cytosine modificationStep 1

Genomic conservation of DNA modification genesStep 2

Glycosyltransferase for arabinose transfer is unknownStep 3

Knowledge Gaps (1)

Missing evidence for identity of arabinose-transferring glycosyltransferase

Source

Synthesis for current paper

Connections (5)

Serratia phage 92A1 uses arabinose to hypermodify genomeAssociation

Conserved DNA modification pathway in phage 92A1 and RB69Association

Conserved arabinose-UDP biosynthesis genes in phagesAssociation

Phage U32 peptidase may have novel DNA modification roleAssociation

Unknown glycosyltransferase role in Serratia phage 92A1Association