Association·arcadia

NAXE is required for the NAD(P)HX repair system

Claim that NAXE protein is necessary for proper functioning of the NAD(P)HX repair system; mutations in NAXE disrupt repair and lead to neurometabolic disorders.

Confidence
100%
active

Evidence Quote

“NAXE mutations disrupt cellular NAD(P)HX repair system”

Relationship

NAXE protein enables NAD(P)HX repair system

Arguments

NAXE proteinsubject
NAD(P)HX repair systemobject

Connections (3)

NAXE mutations impair NAD(P)HX repair and cause neurometabolic disorderInferenceChain
SMN1 protein mutation causes SMAAssociation
NAD(P)HX repair system conservation and relevance across speciesInferenceChain

Evidence

“Evidence from Niehaus et al. (2014) that plants utilize a highly conserved system for repair of NADH and NADPH hydrates.”

Niehaus TD et al. (2014). Plants Utilize a Highly Conserved System for Repair of NADH and NADPH Hydrates doi:10.1104/pp.114.236539 ↗