Label-free neuroimaging detects pain but not itch signals

This reasoning chain synthesizes why minimally invasive, label-free autofluorescence imaging in mice reliably reports brain activity in response to tactile and pain stimuli, but not itch. It incorporates evidence for robust oscillatory brain activity after capsaicin-induced pain yet inconclusive results for histamine-induced itch, possibly due to lower cortical neuron responsivity and technical sensitivity ceilings.

Reasoning Steps (3)

Knowledge Gaps (1)

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