Association·arcadia
High PPK1 structural similarity relates to virulence traits in pathogens
Claim that bacterial strains with PPK1 proteins showing > 0.98 TM-score similarity to Accumulibacter PPK1 have enhanced virulence related to polyphosphate accumulation
Confidence
90%
active
Evidence Quote
“Human pathogens with PPK1 > 0.98 TM-score are linked to virulence traits including biofilm, motility, and immune evasion”
Relationship
Pseudomonas aeruginosa ATCC15692 relates Pathogen virulence
Connections (13)
Polyphosphate kinase PPK1Factor
Acinetobacter baumannii strain 83444Factor
Phage U32 peptidase may have novel DNA modification roleAssociation
Accumulibacter PPK1 proteinFactor
PPK1 structural similarity underpins virulence traits in human pathogensInferenceChain
Structural similarity underlies polyphosphate accumulation patternsInferenceChain
PPK1 structure similarity explains polyphosphate accumulation and virulence traitsInferenceChain
Pseudomonas aeruginosa polyphosphate kinaseFactor
Gonococcal polyphosphate pseudo-capsuleFactor
Ralstonia solanacearum strain UW386Factor
Nitrospira speciesFactor
Gemmatimonadetes speciesFactor
Role of type 4 pili and PPK2 in Ralstonia solanacearum virulence and polyphosphate metabolismInferenceChain
Evidence
“Inline reference about attenuation of Acinetobacter baumannii virulence by inhibition of polyphosphate kinase 1 with repurposed drugs”
Gautam LK et al. (2021). Attenuation of Acinetobacter baumannii virulence by inhibition of polyphosphate kinase 1 with repurposed drugs doi:10.1016/j.micres.2020.126627 ↗
“Evidence that Ralstonia solanacearum requires type 4 pili for surface adhesion, natural transformation, and virulence as reported by Zhang et al. (2002).”
Synthesis for current paper