InferenceChain·arcadia

HCMV US28 chemokine receptor signaling mechanisms

Integrates evidence on the broad chemokine binding and signaling capacity of the HCMV US28 receptor, highlighting its functional selectivity and viral immune escape strategy.

Confidence
90%
◑partialactivecomplexity: mid

Reasoning Steps (3)

US28 binds multiple chemokines with high affinityStep 1
Functional selectivity of US28 signalingStep 2
Viral chemokine sequestration as immune escapeStep 3

Source

Synthesis for current paper

Connections (1)

Viral US28 signals with chemokine agonist degeneracyAssociation