Genetic architecture explains AMR phenotypes in E. coli 7k dataset | ARCADIA FyloGraph | FyloGraph

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InferenceChain·arcadia

Genetic architecture explains AMR phenotypes in E. coli 7k dataset

Logical reasoning connecting evolutionary evidence, phylogenetic diversity, and detection of resistance loci with the reliable prediction of antimicrobial resistance phenotypes from genomic data.

Confidence

90%

◑partialactivecomplexity: mid

Reasoning Steps (3)

Purifying selection and stable core genomeStep 1

Diverse evolutionary scales in phylogeneticsStep 2

Associations of resistance loci with AMR phenotypesStep 3

Source

Synthesis for current paper

Connections (5)

gyrA mutations increase ciprofloxacin resistanceAssociation

parC mutation increases ciprofloxacin resistanceAssociation

Class A beta-lactamase (TEM-1) fragment linked to ampicillin resistanceAssociation

Tn3 transposon family components linked to ampicillin resistanceAssociation

AadA family proteins associated with trimethoprim/sulfamethoxazole resistanceAssociation