Genetic architecture explains AMR phenotypes in E. coli | ARCADIA FyloGraph | FyloGraph

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Genetic architecture explains AMR phenotypes in E. coli — ARCADIA Knowledge Graph

InferenceChain·arcadia

Genetic architecture explains AMR phenotypes in E. coli

Reasoning chain explaining how distinct genetic architectures underpin different antimicrobial resistance phenotypes across diverse evolutionary scales in the E. coli 7k dataset.

Confidence

90%

◑partialactivecomplexity: mid

Reasoning Steps (3)

Ordered mutational pathway for ciprofloxacin resistanceStep 1

Accessory genome components drive ampicillin resistanceStep 2

Complex marker associations in trimethoprim/sulfamethoxazole resistanceStep 3

Source

Predicting antimicrobial resistance phenotypes across 7,000 E. coli genomes

Connections (6)

gyrA mutations increase ciprofloxacin resistanceAssociation

parC mutation increases ciprofloxacin resistanceAssociation

Class A beta-lactamase (TEM-1) fragment linked to ampicillin resistanceAssociation

Tn3 transposon family components linked to ampicillin resistanceAssociation

AadA family proteins associated with trimethoprim/sulfamethoxazole resistanceAssociation

GNAT family proteins associated with trimethoprim/sulfamethoxazole resistanceAssociation