Detection pipeline enables discovery of protein structural mimicry
Claim that the newly developed computational detection pipeline allows discovery of parasite protein structural mimicry cases.
Evidence Quote
“The detection pipeline enables systematic discovery of parasite protein structural mimicry.”
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Evidence
“Evidence that the developed structural mimicry detection pipeline successfully recovers well-studied viral protein mimics and is ready for wider deployment.”
“Summarizes the workflow, functions, tool choices, and evaluation of the peptigate pipeline for predicting and annotating bioactive peptides from transcriptomes and protein sequences.”
“Reference describing Viro3D, a comprehensive database of virus protein structure predictions.”
“Reference describing the AlphaFold method for highly accurate protein structure prediction.”
“Reference describing Foldseek, a fast and accurate protein structure search tool.”
“Reference describing ColabFold, a tool to facilitate protein folding predictions.”
“Evidence line providing support from the reference on using Chlamydomonas flagellum as a model for human ciliary disease.”
“Evidence line showing restoration of motility in Chlamydomonas mutants modeling spermatogenic failure.”
“Evidence supporting characterization of yeast mutants defective in glycerol catabolism.”
“Evidence describing the phenotypes of a Chlamydomonas insertional mutant disrupting flagellar central pair microtubule-associated structures.”
“Evidence summarizing selection with recurrent backcrossing to develop congenic lines used for quantitative trait locus analysis.”
“Evidence line summarizing findings that actin cytoskeleton functions are conserved in absence of canonical actin-binding proteins.”
“Evidence summarizing deep learning-based mapping of crawling-cell morphodynamics in feature space.”
“Evidence from Miyata et al. (2020) on the evolutionary history of motility systems across living organisms.”
“Evidence line supporting characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism from the cited reference.”
“Evidence line describing selection with recurrent backcrossing to develop congenic lines for quantitative trait locus analysis, supported by the cited reference.”