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Detecting HGT requires multiple computational approaches

Claim that detection of HGT events requires use of multiple computational strategies due to methodological trade-offs, genomic signature diversity, and risk of false positives such as contamination.

Confidence
100%
active

Evidence Quote

“Detecting HGT in genome sequence data can be difficult, or at the very least, may require multiple strategies to find different types of transfer events.”

Relationship

Horizontal gene transfer detection requires Multiple computational strategies

Arguments

Horizontal gene transfer detectionsubject
Multiple computational strategiesobject

Connections (3)

Trade-offs and limitations in HGT detectionInferenceChain
Genome contamination yields HGT false positivesAssociation
Mechanisms and barriers shape HGT patternsInferenceChain

Evidence

“DOI reference to study on restriction endonuclease as HGT barrier in S. aureus”

Corvaglia AR et al. (2010). A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical Staphylococcus aureus strains doi:10.1073/pnas.1000489107 ↗

“DOI reference to study on CRISPR interference restricting HGT in staphylococci”

Marraffini LA & Sontheimer EJ (2008). CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA doi:10.1126/science.1165771 ↗

“Reference for Ravenhall M et al. (2015) review on inference of HGT”

Ravenhall M et al. (2015). Inferring Horizontal Gene Transfer doi:10.1371/journal.pcbi.1004095 ↗