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Chlorarachniophyte extensions require Arp2/3 complex — ARCADIA Knowledge Graph

Association·arcadia

Chlorarachniophyte extensions require Arp2/3 complex

Claim that formation of extensions in chlorarachniophytes is dependent on the presence of the Arp2/3 protein complex.

Confidence
90%
active

Evidence Quote

“Formation of extensions requires Arp2/3 complex”

Relationship

Chlorarachniophyte extensions requires Arp2/3 complex

Arguments

Chlorarachniophyte extensionssubject
Arp2/3 complexobject

Connections (3)

Microchamber components enable microscopyAssociation
Actin nucleators are required for extension formationAssociation
Reasoning on actin/cytoskeletal protein diversity and extension functionsInferenceChain

Evidence

“Quantitative and qualitative evidence that actin nucleator inhibitors such as SMIFH2 (formin inhibitor) and CK-666 (Arp2/3 complex inhibitor) reduce or block the formation of chlorarachniophyte cellular extensions, while actin polymerization inhibitors mainly reduce their length.”

Main paper

“Reference reviewing cilia, ciliogenesis, and the actin cytoskeleton.”

Smith CEL et al. (2020). Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please doi:10.3389/fcell.2020.622822 ↗