Association·arcadia

Chlorarachniophyte extensions require Arp2/3 complex

Claim that formation of extensions in chlorarachniophytes is dependent on the presence of the Arp2/3 protein complex.

Confidence
90%
active

Evidence Quote

Formation of extensions requires Arp2/3 complex

Relationship

Chlorarachniophyte extensions requires Arp2/3 complex

Evidence

Quantitative and qualitative evidence that actin nucleator inhibitors such as SMIFH2 (formin inhibitor) and CK-666 (Arp2/3 complex inhibitor) reduce or block the formation of chlorarachniophyte cellular extensions, while actin polymerization inhibitors mainly reduce their length.

Main paper

Reference reviewing cilia, ciliogenesis, and the actin cytoskeleton.

Smith CEL et al. (2020). Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please doi:10.3389/fcell.2020.622822