Association·arcadia
CFEM protein associated with fungal pathogenicity
Claim that CFEM domain-containing membrane protein found near polyketide synthase gene region in Cordyceps is associated with fungal pathogenicity.
Confidence
70%
active
Evidence Quote
“CFEM domain-containing protein is associated with fungal pathogenicity”
Relationship
CFEM domain-containing membrane protein in Cordyceps associated Cordyceps virulence and host membrane disruption
Arguments
Connections (4)
Reasoning about functional significance of HGT candidate genes in fungal behavioral manipulation and pathogenicityInferenceChain
Polyketide synthase gene derived from actinomycetes may mediate bioactive metabolite production in CordycepsAssociation
Horizontally transferred genes support host manipulation and pathogenicityInferenceChain
CFEM, phospholipase, and fungal virulence reasoning chainInferenceChain
Evidence
“Reference on the CFEM domain in fungi, providing systematic analyses of its uniqueness and putative evolutionary origins.”
Zhang Z-N et al. (2015). Systematic analyses reveal uniqueness and origin of the CFEM domain in fungi doi:10.1038/srep13032 ↗
“Reference describing biologically active fungal secondary metabolites, relevant to fungal metabolism and bioactive compounds.”
Bills GF & Gloer JB (2016). Biologically Active Secondary Metabolites from the Fungi doi:10.1128/microbiolspec.funk-0009-2016 ↗
“Reference describing the central pair protein Cpc1 with an adenylate kinase domain in Chlamydomonas”
Zhang H & Mitchell DR (2004). Cpc1, a Chlamydomonas central pair protein with an adenylate kinase domain doi:10.1242/jcs.01297 ↗