Association·arcadia

Capsid proteins interact with and package RNA

Claim that tick-encoded viral capsid proteins, especially RNA nucleocapsids and Gag-Pol, interact with and help package RNA molecules.

Confidence
70%
active

Evidence Quote

Tick-encoded capsid types are RNA nucleocapsids and retrotransposon Gag-Pol proteins, both interact with and help package RNA molecules.

Relationship

RNA nucleocapsid capsid packages RNA molecule

Evidence

Reference to Pastuzyn et al. (2018) publication on the neuronal gene Arc as a repurposed retrotransposon protein.

Pastuzyn ED et al. (2018). The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer doi:10.1016/j.cell.2017.12.024

Ding B, Qin Y, Chen M. (2016). Review of nucleocapsid proteins’ functions.

Ding B et al. (2016). Nucleocapsid proteins: roles beyond viral RNA packaging. doi:10.1002/wrna.1326

Luo M, Terrell JR, Mcmanus SA. (2020). Structural study of viral nucleocapsids.

Luo M et al. (2020). Nucleocapsid Structure of Negative Strand RNA Virus. doi:10.3390/v12080835