Association·arcadia
C. elegans assay enables high-throughput phenotypic screening
Claim that the described C. elegans floe assay can be adapted for high-throughput phenotypic genetic or drug screening, including use in disease modeling contexts such as retinitis pigmentosa.
Confidence
80%
active
Evidence Quote
“This technology's most exciting application is in high-throughput phenotypic genetic or drug screening; can enable disease modeling.”
Relationship
C. elegans floe workflow enables High-throughput phenotypic screening
Connections (3)
Evidence
“Reference on systematic creation and phenotyping of Mendelian disease models in C. elegans.”
O’Brien TJ et al. (2023). Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing doi:10.7554/elife.92491.1 ↗
“Reference on interpretable behavioural features for quantitative phenotyping of C. elegans.”
Javer A et al. (2018). Powerful and interpretable behavioural features for quantitative phenotyping of Caenorhabditis elegans doi:10.1098/rstb.2017.0375 ↗
“Reference on automatic tracking of feeding behavior in C. elegans populations.”
Bonnard E et al. (2022). Automatically tracking feeding behavior in populations of foraging C. elegans doi:10.7554/elife.77252 ↗
“Reference on using micro-particle image velocimetry to analyze C. elegans propulsion.”
Kuo W-J et al. (2014). Characterizations of kinetic power and propulsion of the nematode Caenorhabditis elegans based on a micro-particle image velocimetry system doi:10.1063/1.4872061 ↗
“Reference on light microscopy applications and challenges in systems biology.”
Light microscopy applications in systems biology: opportunities and challenges doi:10.1186/1478-811x-11-24 ↗
“Reference on using DeepLabCut for 3D markerless pose estimation.”
Nath T et al. (2019). Using DeepLabCut for 3D markerless pose estimation across species and behaviors doi:10.1038/s41596-019-0176-0 ↗