InferenceChain·arcadia

Actin proteins targeted by CK-666 explain inhibition mechanism

Reasoning that CK-666's inhibition effects in P. tricornutum may be due to binding and inhibiting polymerizable actin proteins Act1 and Act2 despite lack of canonical Arp2/3 complex, based on predicted structural binding and conserved enzymatic features.

Confidence
90%
◑partialactivecomplexity: mid

Reasoning Steps (3)

PtAct1 and PtAct2 have binding similarity to Bos taurus Arp2Step 1
PtAct1 and PtAct2 show high actin polymerization and ATPase activityStep 2
Absence of canonical Arp2/3 complex in P. tricornutumStep 3

Source

Synthesis for current paper