ReasoningCheckpoint·arcadia

48/80 induces toxicity at assay concentrations

Compound 48/80 causes significant cell lysis/toxicity in HMC1.2 and RBL-2H3 at the concentrations needed to induce degranulation, confounding interpretation of degranulation data and limiting utility of the assay.

Confidence
80%
◑partialactive

Part of Chain

Assay inactivation due to toxicity and lack of suitable activator